Your judgment, minus the busywork.

TPN2.0 gathers each infant's data, drafts a safe, compoundable formula, and checks every guardrail before you see it. Our goal is simply to make your control easier. You review, adjust, and sign the way you always have, minus the manual arithmetic.

Dosing as individual as your patients

Clinicians, advanced practitioners, dietitians, and clinical pharmacists all touch the same PN order in different ways. TPN2.0 is built with features for each of those workflows, so every member of the team gets what they need without stepping on each other.

+ MORE

EHR-integrated

Pulls labs, weight, feeds, and IV lines from the chart, and writes the finished order back to your existing form.

No manual volume math

Set the total fluid goal; TPN2.0 accounts for enteral feeds and IV lines automatically, giving you what's left for PN.

Personalized recommendation

A compoundable formula tuned to each infant, from models validated on real world evidence.

Built-in safety

Every order is checked against your limits, osmolarity, and calcium-phosphate solubility before you sign.

One fluid goal. The rest is easy.

Feeds and IV lines arrive from the chart

You set one total fluid goal

It solves the full PN volume and composition

Change any recommendation you want

Every recommendation shows its reasoning

Nutrition tracking across the stay

The finished order writes back to your order form

Your limits, built into every recommendation.

Your pharmacy's soft and hard limits shape both the dose TPN2.0 recommends and the range you can adjust it within. Electrolytes balance and other guardrails, like osmolarity and calcium–phosphate solubility, are built in the same way.

Your pharmacy is in control

We work with your pharmacy team to customize these safety guardrails, giving them control over dose limits, formulary, ingredient availability, and more.

See how the pharmacy module works

Try one below: as you change the mixture, the adjustable maximum always stays under the CaPO₄ solubility curve.

Amino acids (% AA)

Dextrose

Low dextrose drops onto the conservative safety line.

Cysteine added

Cysteine lowers pH and raises solubility.

Calcium1.3 mEq/kg

Phosphate0.9 mmol/kg

within solubilityblocked by the curve

Individualized care, grounded in the evidence.

Neonatal parenteral nutrition is one of the most complex orders in the NICU. It is a high-alert medication built from dozens of components and assembled for one infant at a time (AJHP, 2024). Best-practice targets keep tightening toward individualized dosing, and are revised as the evidence grows (JPEN, 2023). TPN2.0 was built to meet them, and to keep learning as they move.

The evidence is consistent:

Practice varies widely, this applies both across institutions and between prescribers within a unit. (JPEN, 2024; NCP, 2026).

Care often departs from the standard, reports show under-dosing calcium and phosphorus and some not macro targets on the first day (Nutrients, 2024; Nutrients, 2023).

Under-personalized nutrition reaches the patient, linked to complications such as metabolic bone disease and to cumulative deficits that impair growth (Int J Mol Sci, 2022; Children, 2025; Ital J Pediatr, 2023).

TPN2.0 outperformed practice, matching expert dosing both retrospectively and in a blinded study (Nature Medicine, 2025).

See more detail about our model here

Do research like this on your own data

We routinely ran analyses across a decade of orders. With QI & Research, you can easily do research on your own NICU's cohort.

Explore QI & Research

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